Sex-related differences in the analgesic response to the rat tail immersion test
Braz. j. med. biol. res
; 27(7): 1669-1672, Jul. 1994.
Article
en En
| LILACS
| ID: lil-319776
Biblioteca responsable:
BR1.1
ABSTRACT
The analgesic response was evaluated by the tail immersion test in adult male (N = 30), female (N = 21) and androgenized female Wistar rats (N = 15). The reaction time for tail withdrawal from the hot water bath was faster for male than for female rats (3.48 +/- 0.12 vs 6.46 +/- 0.42 s). The reaction time of androgenized female rats was similar to that of male rats (3.08 +/- 0.16 s). Blockade of opiate receptors with naloxone (2 mg/kg, ip) decreased the sensitivity to the noxious stimuli in males (4.08 +/- 0.10 s) and in androgenized females (3.69 +/- 0.19 s) but increased it in female rats (5.01 +/- 0.41 s). These data show sex-related differences in the analgesic response evaluated by the tail immersion test and indicate that administration of androgens to newborn female rats affects their pain sensitivity.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Cola (estructura animal)
/
Caracteres Sexuales
/
Naloxona
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Brasil