Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy
Int. braz. j. urol
; 30(1): 12-17, Jan.-Feb. 2004. tab
Article
en En
| LILACS
| ID: lil-359778
Biblioteca responsable:
BR1.1
RESUMO
OBJECTIVES:
To analyze the behavior of the prostate specific antigen velocity (PSAV) in localized prostate adenocarcinoma. MATERIALS ANDMETHODS:
We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups age, initial PSA value, clinical stage, tumor volume and Gleason score.RESULTS:
The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6 percent and 59.8 percent when compared with the initial PSA value (p < 0.0001), clinical stage (p = 0.0002), tumor volume (p < 0.0001) and Gleason score (p = 0.0009).CONCLUSION:
PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20 percent and Gleason score lower than 7.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Prostatectomía
/
Neoplasias de la Próstata
/
Adenocarcinoma
/
Antígeno Prostático Específico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil