Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation
Biol. Res
; 38(2/3): 121-146, 2005. ilus
Article
en En
| LILACS
| ID: lil-424717
Biblioteca responsable:
CL1.1
ABSTRACT
Ribosome recruitment to eukaryotic mRNAs is generally thought to occur by a scanning mechanism, whereby the 40S ribosomal subunit binds in the vicinity of the 5'cap structure of the mRNA and scans until an AUG codon is encountered in an appropriate sequence context. Study of the picornaviruses allowed the characterization of an alternative mechanism of translation initiation. Picornaviruses can initiate translation via an internal ribosome entry segment (IRES), an RNA structure that directly recruits the 40S ribosomal subunits in a cap and 5' end independent fashion. Since its discovery, the notion of IRESs has extended to a number of different virus families and cellular RNAs. This review summarizes features of both cap-dependent and IRES-dependent mechanisms of translation initiation and discusses the role of cis-acting elements, which include the 5'cap, the 5'-untranslated region (UTR) and the poly(A) tail as well as the possible roles of IRESs as part of a cellular stress response mechanism and in the virus replication cycle.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
ARN Mensajero
/
Proteínas
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Factores Eucarióticos de Iniciación
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Células Eucariotas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Biol. Res
Asunto de la revista:
BIOLOGIA
Año:
2005
Tipo del documento:
Article
/
Project document
País de afiliación:
Chile