Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants
Braz. j. med. biol. res
; 44(6): 500-513, June 2011. ilus, tab
Article
en En
| LILACS, SES-SP
| ID: lil-589971
Biblioteca responsable:
BR1.1
ABSTRACT
Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvants in a more rational design. The purpose of this review is to discuss the recent advances in this field regarding the attempts to determine the molecular basis and the general mechanisms underlying the development of new adjuvants, with particular emphasis on the activation of receptors of innate immune recognition. One can anticipate that the use of these novel adjuvants will also provide a window of opportunities for the development of new vaccines.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
SES-SP
Asunto principal:
Vacunas
/
Factores de Virulencia
/
Receptores de Reconocimiento de Patrones
/
Inmunidad Adaptativa
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil