Atypical chronic myeloid leukemia with t(9; 22)(p24,11. 2), a BCR-JAK2 fusion gene
Rev. bras. hematol. hemoter
; 35(3): 218-219, jun. 2013. tab, graf
Article
en En
| LILACS
| ID: lil-681980
Biblioteca responsable:
BR408.1
Ubicación: BR408.1
ABSTRACT
We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Leucemia Mieloide
/
Proteínas Proto-Oncogénicas c-bcr
/
Leucemia Mieloide Crónica Atípica BCR-ABL Negativa
/
Enfermedades Mielodisplásicas-Mieloproliferativas
Límite:
Humans
/
Male
Idioma:
En
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
HEMATOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil