Effect of adenosine on gonadotropin and prolactin secretion by hemipituitaries in vitro
Braz. j. med. biol. res
; 22(6): 783-5, June 1989. ilus, tab
Article
en En
| LILACS
| ID: lil-75243
Biblioteca responsable:
BR26.1
ABSTRACT
Incubation of hemipituitaries from male rats (200-220 g) with 10 nM to 1 micronM adenosine induced a dose-dependent decrease of the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) into the medium, and increased prolactin (PRL) secretion. The effects of 10 nM adenosine were blocked by 100 nM ceffeine, wereas 100 nM ceffeine alone had also inhibited 10 nM luteinizing hormone-releasing hormone (LHRH)-induced LH and FSH release by > 90%. These data indicate a regulatory role for adenosine in pituitary LH, FSH and PRL release, and also a possible modulatory effect of adenosine on the LHRH-LH and FSH system
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Hipófisis
/
Prolactina
/
Cafeína
/
Hormona Luteinizante
/
Adenosina
/
Hormona Folículo Estimulante
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1989
Tipo del documento:
Article
/
Congress and conference
/
Project document