Medical ozone treatment ameliorates the acute distal colitis in rat
Acta cir. bras
; 31(4): 256-263, Apr. 2016. graf
Article
en En
| LILACS
| ID: lil-781329
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats.METHODS:
Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-α and IL-1β levels. Histolopatological examination was evaluated with Ki-67, IL-1β and VEGF immunostaining densities.RESULTS:
There was significant increase in tissue MDA, MPO activity, TNF-α and IL-1β after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination.CONCLUSIONS:
Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Oxidantes Fotoquímicos
/
Ozono
/
Colitis Ulcerosa
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Article
País de afiliación:
Turquía