A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum.
Chem Pharm Bull (Tokyo)
; 48(7): 1087-9, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-10923847
ABSTRACT
A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,2 0(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 microg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colestenos
/
Cnidarios
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2000
Tipo del documento:
Article
País de afiliación:
Singapur