Reduced flavin: donor and acceptor enzymes and mechanisms of channeling.
Antioxid Redox Signal
; 3(5): 881-97, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11761334
ABSTRACT
Although mechanisms of metabolite channeling have been extensively studied, the nature of reduced flavin transfer from donor to acceptor enzymes remains essentially unexplored. In this review, identities and properties of reduced flavin-producing enzymes (namely flavin reductases) and reduced flavin-requiring processes and enzymes are summarized. By using flavin reductase-luciferase enzyme couples from luminous bacteria, two types of reduced flavin channeling were observed involving the differential transfers of the reduced flavin cofactor and the reduced flavin product of reductase to luciferase. The exact mode of transfer is controlled by the specific makeup of the constituent enzymes within the reductase-luciferase couple. The plausible physiological significance of the monomer-dimer equilibrium of the NADPH-specific flavin reductase from Vibrio harveyi is also discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavinas
Idioma:
En
Revista:
Antioxid Redox Signal
Asunto de la revista:
METABOLISMO
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos