Change in coronary flow reserve on transthoracic Doppler echocardiography after a single high-fat meal in young healthy men.
Ann Intern Med
; 136(7): 523-8, 2002 Apr 02.
Article
en En
| MEDLINE
| ID: mdl-11926787
ABSTRACT
BACKGROUND:
High-fat meals and elevated triglyceride levels are associated with cardiovascular disease. In recent studies of brachial artery vasoactivity, a single high-fat meal reduced endothelial function in young healthy men. It is unknown whether coronary microcirculation is affected after high-fat meals.OBJECTIVE:
To evaluate change in coronary flow reserve after a single high-fat meal.DESIGN:
Controlled interventional study.SETTING:
University hospitals. PATIENTS 15 young healthy men (mean age [+/-SD], 29 +/- 4 years). INTERVENTION Coronary flow reserve was determined by using transthoracic Doppler echocardiography before and after consumption of a high-fat meal in all 15 men and before and after consumption of a low-fat meal in 5 of 15 men. MEASUREMENTS Coronary flow reserve, lipid levels, and hemodynamic characteristics.RESULTS:
In all men, triglyceride levels increased significantly from baseline 5 hours after the high-fat meal, from 1.1 mmol/L to 2.8 mmol/L (100 mg/dL to 250 mg/dL) (P < 0.001). Average coronary flow reserve was 4.02 before and 3.30 5 hours after the high-fat meal (decrease, 18% [95% CI, 13% to 23%]). In the 5 men who received both meals, mean coronary flow reserve decreased by 0.79 after the high-fat meal and increased by 0.07 after the low-fat meal (difference, -0.86 [CI, -1.36 to -0.37]; P = 0.03). Mean triglyceride levels increased by 1.6 mmol/L (140 mg/dL) after the high-fat meal and 0.1 mmol/L (10 mg/dL) after the low-fat meal (difference, 1.5 mmol/L [CI, 0.3 to 2.7 mmol/L], 130 mg/dL [CI, 23 to 236 mg/dL]; P = 0.03).CONCLUSIONS:
Coronary flow reserve decreased after a single high-fat meal in young healthy men. High-fat meals may be detrimental to coronary microcirculation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Grasas de la Dieta
/
Circulación Coronaria
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Ann Intern Med
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos