Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation.
Crit Care Med
; 30(6): 1311-4, 2002 Jun.
Article
en En
| MEDLINE
| ID: mdl-12072687
ABSTRACT
OBJECTIVE:
During hypothermic cardiopulmonary resuscitation with a body core temperature <30 degrees C administration of a vasopressor to support coronary perfusion pressure is controversial. The purpose of the current study was to assess the effects of a single 0.4-unit/kg dose of vasopressin on coronary perfusion pressure, defibrillation success, and 1-hr survival in a pig model of hypothermic closed-chest cardiopulmonary resuscitation combined with rewarming.DESIGN:
Prospective, randomized study in an established pig model.SETTING:
University hospital research laboratory.SUBJECTS:
Fifteen 12- to 16-wk-old domestic pigs.INTERVENTIONS:
Pigs were surface cooled to a body core temperature of 26 degrees C and ventricular fibrillation was induced. After 15 mins of untreated cardiac arrest, manual closed-chest cardiopulmonary resuscitation and thoracic lavage with 40 degrees C warmed tap water were started. After 3 mins of external chest compression, animals were assigned randomly to receive vasopressin (0.4 units/kg, n = 8; or saline placebo, n = 7). Defibrillation was attempted 10 mins after drug administration. MEASUREMENTS AND MAINRESULTS:
Compared with saline placebo treated-animals, coronary perfusion pressure in vasopressin-treated pigs was significantly higher 90 secs (36 +/- 5 mm Hg vs. 7 +/- 4 mm Hg, p =.000) to 10 mins (24 +/- 4 mm Hg vs. 8 +/- 4 mm Hg, p =.000) after drug administration. Restoration of spontaneous circulation and 1 hr survival were significantly higher in vasopressin animals compared with saline placebo (8 of 8 vasopressin pigs vs. 0 of 7 placebo pigs, p <.001).CONCLUSIONS:
A single 0.4-unit/kg dose of vasopressin administered at a body core temperature <30 degrees C significantly improved defibrillation success and 1-hr survival in a pig model of hypothermic cardiopulmonary resuscitation.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasoconstrictores
/
Vasopresinas
/
Reanimación Cardiopulmonar
/
Hipotermia
Límite:
Animals
Idioma:
En
Revista:
Crit Care Med
Año:
2002
Tipo del documento:
Article
País de afiliación:
Austria