[Imidazoline-guanidine site: a subtype of imidazoline receptors]. / Le site imidazolinique-guanidinique: un sous-type de récepteurs imidazoliniques.
Therapie
; 47(6): 519-24, 1992 Nov.
Article
en Fr
| MEDLINE
| ID: mdl-1338740
ABSTRACT
Since the demonstration that imidazoline and guanidinium alpha-2 adrenergic agonists induce some of their functional effects by a "nonadrenergic" mechanism, many efforts have been done to identify an imidazoline receptor. Binding studies have allowed to characterize two classes of potential imidazoline receptors the "(p-amino)clonidine" and the "idazoxan" binding sites. These last, that we named "imidazoline-guanidinium receptive sites" (IGRS) on the basis of their ligand-recognition properties, have been identified, for the first time, in the proximal tubule from rabbit and human kidney. In the present report we will summarize the studies that led us to the characterization of IGRS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Superficie Celular
/
Guanidinas
/
Imidazoles
Límite:
Animals
/
Humans
Idioma:
Fr
Revista:
Therapie
Año:
1992
Tipo del documento:
Article