[Ligase chain reaction. Theory, practical use, prospects]. / Ligaznaia tsepnaia reaktsiia. Teoriia, prakticheskoe primenenie, perspektivy.

The authors present a review of papers on research into ligase chain reaction and its application in microbiology published in scientific periodicals by the end of 2003. The paper covers the theoretical ground of ligase chain reaction methodology, describes typical experimental procedures and gives examples of application of ligase chain reaction in modern diagnostic practice to detect infections, genetic diseases and for gene identification.