Interference between mild and pathogenic strains of infectious bursal disease virus in chickens.
Avian Dis
; 49(1): 99-103, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15839420
ABSTRACT
Infectious bursal disease virus is a contagious, immunosuppressive disease of young chickens that is controlled by vaccination. Cross-protection occurs between different strains of the virus as a result of shared neutralizing epitopes. However, interactions between two antigenically similar strains (a mild and a pathogenic) coinfecting the same host have not been investigated. Groups of specific-pathogen-free chickens were inoculated with a mild strain followed by a pathogenic strain at 0, 16, 24, or 48 hr postinoculation (PI) with a mild strain. Virus persistence and the predominant strain of the virus were determined by reverse transcriptase-polymerase chain reaction and restriction fragment length polymorphism analysis, respectively, in bursas at 2, 4, 8, 14, and 21 days PI with the pathogenic strain. Severity of infection was assessed by the bursa/body weight ratios and histopathologic lesion scores. The mild virus interfered with replication of the pathogenic virus. The greatest interference was observed when the pathogenic strain was inoculated 24 hr PI with the mild strain. The interference phenomenon observed might be due to competition for host receptor sites or production of cytokine(s). This interference phenomenon could have practical implications for vaccine usage and protection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Aves de Corral
/
Interferencia Viral
/
Pollos
/
Infecciones por Birnaviridae
/
Virus de la Enfermedad Infecciosa de la Bolsa
Límite:
Animals
Idioma:
En
Revista:
Avian Dis
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos