Recycling and EH domain proteins at the synapse.
Brain Res Brain Res Rev
; 49(2): 416-28, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16054223
ABSTRACT
In neurons, a network of endocytic proteins accomplishes highly regulated processes such as synaptic vesicle cycling and the timely internalization of intracellular signaling molecules. In this review, we discuss recent advances on molecular networks created through interactions between proteins bearing the Eps15 homology (EH) domain and partner proteins containing the Asn-Pro-Phe (NPF) motif, which participate in important aspects of neuronal function as the synaptic vesicle cycle, the internalization of nerve growth factor (NGF), the determination of neuronal cell fate, the development of synapses and the trafficking of postsynaptic receptors. We discuss novel functional findings on the role of intersectin and synaptojanin and then we focus on the features of an emerging family of EH domain proteins termed EHDs (EH domain proteins), which are important for endocytic recycling of membrane proteins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Sinapsis
/
Homología de Secuencia de Aminoácido
/
Motivos EF Hand
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Brain Res Brain Res Rev
Asunto de la revista:
CEREBRO
Año:
2005
Tipo del documento:
Article
País de afiliación:
España