Amelioration of ischemia-reperfusion injury of transplanted small intestine by ulinastatin: effects on accumulation and adhesion of neutrophil.
Transplant Proc
; 37(10): 4464-6, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16387146
ABSTRACT
BACKGROUND:
The graft protective effect of ulinastatin (UTI) against ischemia-reperfusion injury in small bowel transplantation (SBT) was verified with a rat SBT model. This study was carried out to investigate the effects of UTI on the accumulation and adhesion of neutrophils.METHODS:
Twenty-four recipients of rat SBTs were randomly divided into a control group and a UTI group. UTI was injected intravenously into the donor (before harvest of the graft) and into the recipient (50,000 U/kg/d). Variables included graft pathological score; myeloperoxidase content (MPO); expression of intercellular adhesion molecule-1 (ICAM-1) in the graft and plasma concentration of tumor necrosis factor (TNF) in the recipient.RESULTS:
The pathological changes of control group grafts were more significant than those of the UTI group. The content of MPO and expression of ICAM-1 in transplanted small intestines were lower among the UTI group as were plasma concentrations of TNF.CONCLUSIONS:
UTI may ameliorate graft ischemia-reperfusion injury in SBT through decreasing accumulation and adhesion of neutrophils.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante Homólogo
/
Glicoproteínas
/
Adhesión Celular
/
Inhibidores de Tripsina
/
Intestino Delgado
/
Neutrófilos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Transplant Proc
Año:
2005
Tipo del documento:
Article
País de afiliación:
China