Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

Hall, Adrian; Bit, Rino A; Brown, Susan H; Chaignot, Helene M; Chessell, Iain P; Coleman, Tanya; Giblin, Gerard M P; Hurst, David N; Kilford, Ian R; Lewell, Xiao Q; Michel, Anton D; Mohamed, Shiyam; Naylor, Alan; Novelli, Riccardo; Skinner, Lee; Spalding, David J; Tang, Sac P; Wilson, Richard J

Hall, Adrian; Bit, Rino A; Brown, Susan H; Chaignot, Helene M; Chessell, Iain P; Coleman, Tanya; Giblin, Gerard M P; Hurst, David N; Kilford, Ian R; Lewell, Xiao Q; Michel, Anton D; Mohamed, Shiyam; Naylor, Alan; Novelli, Riccardo; Skinner, Lee; Spalding, David J; Tang, Sac P; Wilson, Richard J.

Afiliación

Hall A; Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. adrian.2.hall@gsk.com

Bioorg Med Chem Lett ; 16(10): 2666-71, 2006 May 15.

Article en En | MEDLINE | ID: mdl-16503138

RESUMEN

We describe the generation of novel EP(1) receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.

Asunto(s)

Compuestos Heterocíclicos/química; Compuestos Heterocíclicos/farmacología; Receptores de Prostaglandina E/antagonistas & inhibidores; Animales; Técnicas In Vitro; Ratas; Subtipo EP1 de Receptores de Prostaglandina E

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Prostaglandina E / Compuestos Heterocíclicos Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article Pais de publicación: Reino Unido

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