Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
J Nat Prod
; 69(5): 736-41, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16724832
ABSTRACT
A group of new 10mer linear peptides, designated culicinins A-D (1-4), was isolated from the fermentation broth of the entomopathogenic fungus Culicinomyces clavisporus, strain LL-12I252. The structures of the culicinins were determined by a combination of 2D NMR and MS analysis. The major compound, culicinin D (4), exhibited selective inhibitory activity against PTEN-negative MDA468 tumor cells. Studies on the 3D structure of 4 using NOE data and computer modeling revealed a dominant conformation of the right-handed helix.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Hypocreales
/
Antineoplásicos
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Nat Prod
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos