Substituent effects on the in situ activation of the double activated cross-linking reaction.
Nucleic Acids Symp Ser (Oxf)
; (49): 175-6, 2005.
Article
en En
| MEDLINE
| ID: mdl-17150690
ABSTRACT
We have previously reported that the oligonucleotides (ODN) containing 2-amino-6-(1-ethylsulfinyl)vinyl purine derivatives (2) exhibit selective and efficient cross-linking to a cytidine at the target site under neutral conditions. In addition, bis-alkylsulfinyl derivative (3b) as the stable precursor of 2 showed the moderate reactivity. In this study, we have searched other bis-alkylsulfinyl precursors to achieve higher cross-linking ability, and found that acetamidoethyl and hydroxyethyl derivatives showed highly efficient and selective reactivity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
Purinas
/
Compuestos de Vinilo
/
Reactivos de Enlaces Cruzados
/
Citosina
Idioma:
En
Revista:
Nucleic Acids Symp Ser (Oxf)
Año:
2005
Tipo del documento:
Article