Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.
Neurochem Res
; 32(11): 1950-6, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17577666
Natural products, including those derived from plants, have largely contributed to the development of therapeutic drugs. Glutamate is the main excitatory neurotransmitter in the central nervous system and it is also considered a nociceptive neurotransmitter, by acting on peripheral nervous system. For this reason, in this study we investigated the effects of the hydroalcoholic extracts from Drymis winteri (polygodial and drimanial), Phyllanthus (rutin and quercetine), Jathopha elliptica (jatrophone), Hedyosmum brasiliense (13HDS), Ocotea suaveolens (Tormentic acid), Protium kleinii (alphabeta-amyrin), Citrus paradise (naringin), soybean (genistein) and Crataeva nurvala (lupeol), described as having antinociceptive effects, on glutamatergic transmission parameters, such as [(3)H]glutamate binding, [(3)H]glutamate uptake by synaptic vesicles and astrocyte cultures, and synaptosomal [(3)H]glutamate release. All the glutamatergic parameters were affected by one or more of these compounds. Specifically, drimanial and polygodial presented more broad and profound effects, requiring more investigation on their mechanisms. The putative central side effects of these compounds, via the glutamatergic system, are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinaptosomas
/
Encéfalo
/
Extractos Vegetales
/
Transmisión Sináptica
/
Ácido Glutámico
Límite:
Animals
Idioma:
En
Revista:
Neurochem Res
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Estados Unidos