Correlation between cardiac biomarkers and right ventricular enlargement on chest CT in non massive pulmonary embolism.
Thromb Res
; 121(5): 617-24, 2008.
Article
en En
| MEDLINE
| ID: mdl-17716710
ABSTRACT
BACKGROUND:
Troponin I (cTnI), myoglobin, heart-type fatty acid binding protein (H-FABP), and natriuretic peptides (BNP, NTproBNP) were all reported to be elevated in patients with pulmonary embolism (PE).METHODS:
To assess the correlation between the aforementioned markers and helical computed tomography (hCT) right ventricular dysfunction (RVD) in non massive PE, we performed this prospective pilot study on 50 patients.RESULTS:
Patients with RVD had significant higher natriuretic peptides prevalence than cardiomyocytes damage-related markers (48% vs 20%, P=0.006). Significant prevalence differences were observed only for natriuretic peptides when patients with RVD and those without were compared (74% vs 33% for NT-pro BNP, P=0.005 and 65% vs 22% for BNP, P=0.003). Patients with RVD had significant higher biomarkers median plasmatic values than those without (BNP 170 vs 36 pg/ml, P=0.0027; NT-proBNP 1369 vs 170.7 pg/ml, P=0.0024; cTnI 0.032 vs 0 ng/ml, P=0.0034; H-FABP 4.32 vs 2.23 ng/ml, P=0.0032; myoglobin 36.7 vs 28.2 ng/ml, P=0.03). Significant correlations were only obtained between RV/LV index and plasmatic natriuretic peptides (NT-proBNP r=0.36, P=0.009; BNP r=0.28; P=0.047).CONCLUSIONS:
Natriuretic peptides prevalence elevation and median values are significantly higher when RVD is present and significantly correlate with hCT RVD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Embolia Pulmonar
/
Radiografía Torácica
/
Hipertrofia Ventricular Derecha
/
Tomografía Computarizada Espiral
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Thromb Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Suiza