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Valacyclovir treatment in Epstein-Barr virus subset chronic fatigue syndrome: thirty-six months follow-up.
Lerner, A Martin; Beqaj, Safedin H; Deeter, Robert G; Fitzgerald, James T.
Afiliación
  • Lerner AM; Department of Medicine, William Beaumont Hospital, Royal Oak, MI, USA. amartinlerner@yahoo.com
In Vivo ; 21(5): 707-13, 2007.
Article en En | MEDLINE | ID: mdl-18019402
BACKGROUND: We hypothesized that subset classification of Epstein-Barr virus (EBV) in chronic fatigue syndrome (CFS) is required. At first, a blinded-random placebo-controlled trial of valacyclovir in EBV CFS subset was performed (Group 1), and this EBV subset was followed for thirty-six months (Group 2). Patients were given valacyclovir at 14.3 mg/kg every 6 hours. The validated Energy Index (EI) point score assessing physical functional capacity, Holter monitor, multigated (radionuclide) MUGA rest/stress ventriculographic examination, EBV serum IgM viral capsid antibodies (VCA), and EBV early antigen diffuse (EA) were followed. After six-months, Group 1 CFS patients receiving valacyclovir experienced an increased mean least square EI point score +1.12 units (122 kcal/day), while the placebo cohort increased +0.42 EI units (65 kcal/day). EI point scores at Group 2 increased progressively. Sinus tachycardias decreased and abnormal cardiac wall motion improved. Serum antibody titers to EBV VCA IgM decreased. Patients resumed normal activities.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Valina / Aciclovir / Síndrome de Fatiga Crónica / Herpesvirus Humano 4 / Mononucleosis Infecciosa Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Grecia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Valina / Aciclovir / Síndrome de Fatiga Crónica / Herpesvirus Humano 4 / Mononucleosis Infecciosa Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Grecia