Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Cancer Invest
; 26(7): 698-707, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18608208
Statins have antiproliferative and anti-tumoral effects in MCF-7 cells. We determined the effect of statins upon MCF-7 cell cycle, toxicity, cell death, reactive oxygen species (ROS) production and mitochondrial membrane potential. Fluvastatin, simvastatin and atorvastatin inhibited cell proliferation. Antiproliferation was associated with a decrease in the DNA synthesis and a cell cycle arrest in the G1 and G2/M phases. A loss in the mitochondrial membrane potential was observed with fluvastatin. Statins induced increase in ROS production that was associated with cell death, which was abrogated by the antioxidant NAC. Our results suggest that the cytotoxic effect observed is mediated by an oxidative stress.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Ciclo Celular
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Apoptosis
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Estrés Oxidativo
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Antineoplásicos
Límite:
Female
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Humans
Idioma:
En
Revista:
Cancer Invest
Año:
2008
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Reino Unido