Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
J Nat Prod
; 72(3): 496-9, 2009 Mar 27.
Article
en En
| MEDLINE
| ID: mdl-19199816
ABSTRACT
The effectiveness of precursor-directed biosynthesis to generate diazepinomicin (1) analogues with varied ring-A substitutents was investigated by feeding commercially available, potential ring-A precursors such as fluorinated tryptophans, halogenated anthranilates, and various substituted indoles into growing actinomycete culture DPJ15 (genus Micromonospora). Two new monofluorinated diazepinomicin analogues (2 and 3) were identified and characterized by spectroscopic methods. Both derivatives showed modest antibacterial activity against the Gram-positive coccus Staphylococcus aureus with MIC values in the range 8-32 microg/mL.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dibenzazepinas
/
Hidrocarburos Fluorados
/
Indoles
/
Micromonospora
Idioma:
En
Revista:
J Nat Prod
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos