Synthesis and antimalarial activities of optically active labdane-type diterpenes.
Nat Prod Res
; 23(10): 891-902, 2009.
Article
en En
| MEDLINE
| ID: mdl-19521902
An efficient method for the synthesis of optically active labdane-type diterpenes from (+)-manool 8 is described. We prepared the natural labdane-type diterpene 5 via key intermediate peroxide 9, and synthetic hydroxybutenolides 6 and 7 via a furan photosensitised oxygenation reaction of labdafuran (14). Compounds 5, 6, 7 and 9 were evaluated as inhibitors of the beta-haematin formation and globin proteolysis, and then were assayed in a malarial murine model. Compound 9 was the most promising compound, showing a positive correlation between in vitro and in vivo activities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium berghei
/
Diterpenos
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Venezuela
Pais de publicación:
Reino Unido