Mutual associations between malignancy, age, gender, and subsite incidence of colorectal cancer.
Anticancer Res
; 29(9): 3721-6, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19667170
ABSTRACT
BACKGROUND:
A cross-sectional study was performed on a cohort of colorectal cancer (CRC) patients to reveal any influence of age, gender, and subsite on grades of malignancy. PATIENTS ANDMETHODS:
Data from histopathological grading according to WHO criteria were pooled into groups of low-grade (well and moderately differentiated) and high-grade (poorly and undifferentiated) cancer and analyzed for associations.RESULTS:
In general, women with CRC were significantly older than men (p<0.05). In particular, women with high-grade cancer in the proximal and distal colon had a median age of 75 years and were thus 10-15 years older (p<0.01 and p<0.05, respectively) than their male counterparts. In contrast, high-grade rectal cancer developed in both genders around the early age of 60 years.CONCLUSION:
Women are protected from more aggressive cancer in the colon though not in the rectum until well after menopause. This likely reflects the differential sensitivity of the mucosa at these sites against the anticancer effects triggered by activation of estrogen receptor-beta.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Factores Sexuales
/
Factores de Edad
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Anticancer Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Austria