The relationship of oral contraceptive use to rheumatoid arthritis.

ABSTRACT

PIP: A possible association between oral contraceptive (OC) use and rheumatoid arthritis was investigated in the 71 women aged 17-45 years of age enrolled at Washington's Group Health Cooperative who were newly diagnosed with this condition in the period 1977-86. 280 matched controls were randomly selected for the Cooperative's file of pharmacy users. Among women with rheumatoid arthritis, 16 (23%) were current OC users, 10 (14%) were past users, and 45 (63%) were never-users. Among controls, 37 (13%) were current users, 44 (16%) were past users, and 203 (71%) were never-users. The relative risk of rheumatoid arthritis was 2.0 (95% confidence interval, 0.97-4.2) in current OC users compared with never-users. The relative risk for past use compared with never-use was 1.0 (0.4-2.2). The duration of OC use or the OC's estrogen content did not have a significant impact on the risk of rheumatoid arthritis. These findings suggest that there is no association between OC use and rheumatoid arthritis and contradict earlier studies that found OC use to exert a protective effect on the development of rheumatoid arthritis. The only factor identified as predictive of a new diagnosis of rheumatoid arthritis was pregnancy completion within the past 24 months (relative risk, 4.1; 95% confidence interval, 1.5-11.2).