Target sites of polymyxin B ototoxicity.
Eur Arch Otorhinolaryngol
; 247(2): 129-30, 1990.
Article
en En
| MEDLINE
| ID: mdl-2156537
ABSTRACT
The present study was undertaken to determine the target sites of polymyxin B ototoxicity. This drug, at the concentration of 1 mM, was perfused through the scala tympani of the guinea pig cochlea, and cochlear microphonics and endocochlear potentials were monitored. Both cochlear potentials altered but in an independent manner. These findings indicated that not only the organ of Corti but also another tissue is involved in the ototoxicity produced. The best locus for this is the vascular stria.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimixina B
/
Potenciales Microfónicos de la Cóclea
/
Polimixinas
/
Potenciales Evocados Auditivos
Límite:
Animals
Idioma:
En
Revista:
Eur Arch Otorhinolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón