Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation.
Prilozi
; 32(1): 13-44, 2011.
Article
en En
| MEDLINE
| ID: mdl-21822176
The technology platforms for proteome analysis have advanced considerably over the last few years. Due to these improvements the number of studies on the analysis of the proteome/peptidome with the aim of defining biomarkers has escalated. In this review, we will summarise the technical aspects that relate to the proteomics field targeting the discovery of biomarkers for disease diagnosis. We will describe the course from biomarker discovery or 'potential' biomarkers to those that are clinically important. We also present several examples of successful proteomic studies that have defined 'biomarker patterns' for clinical applications, focussed on urine as a material source and capillary electrophoresis coupled mass spectrometry as a technology. Finally, current challenges and considerations for future studies will be discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Proteoma
/
Proteómica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Prilozi
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Alemania