Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors.
Dalton Trans
; 42(27): 9799-802, 2013 Jul 21.
Article
en En
| MEDLINE
| ID: mdl-23525213
ABSTRACT
Binding of Leu-enkephalin and [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin to the recently published crystal structures of the µ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Rodio
/
Encefalina Leucina
/
Receptores Opioides
Idioma:
En
Revista:
Dalton Trans
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania