Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.

Keeney, Jeriel T R; Förster, Sarah; Sultana, Rukhsana; Brewer, Lawrence D; Latimer, Caitlin S; Cai, Jian; Klein, Jon B; Porter, Nada M; Butterfield, D Allan

Keeney, Jeriel T R; Förster, Sarah; Sultana, Rukhsana; Brewer, Lawrence D; Latimer, Caitlin S; Cai, Jian; Klein, Jon B; Porter, Nada M; Butterfield, D Allan.

Afiliación

Keeney JTR; Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Förster S; Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Sultana R; Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Brewer LD; Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Latimer CS; Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Cai J; Division of Nephrology, Department of Medicine and Proteomics Center, University of Louisville, Louisville, KY 40292, USA.
Klein JB; Division of Nephrology, Department of Medicine and Proteomics Center, University of Louisville, Louisville, KY 40292, USA.
Porter NM; Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Butterfield DA; Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. Electronic address: dabcns@uky.edu.

Free Radic Biol Med ; 65: 324-334, 2013 Dec.

Article en En | MEDLINE | ID: mdl-23872023

Asunto(s)

Encéfalo/metabolismo; Trastornos del Conocimiento/etiología; Tirosina/metabolismo; Deficiencia de Vitamina D/complicaciones; Deficiencia de Vitamina D/metabolismo; Envejecimiento/metabolismo; Animales; Western Blotting; Trastornos del Conocimiento/metabolismo; Dieta; Modelos Animales de Enfermedad; Focalización Isoeléctrica; Masculino; Espectrometría de Masas; Nitrosación; Proteómica; Ratas; Ratas Endogámicas F344; Tirosina/análogos & derivados

Palabras clave

1α,25-(OH)(2) VitD; 25-OH VitD; 2D-PAGE; 3-NT; 3-Nitrotyrosine; 3-nitrotyrosine; 5-bromo-4-chloro-3-indolyl-phosphate; 6-PFK; 6-phosphofructokinase; ALP; Aß; BCIP; BSA; Cognitive decline; DI; DTT; FT; Fourier transform; Free radicals; GPx; IA; IEF; IPI; IPL; International Protein Index; MS; Metabolism; MnSOD; NBT; NF-κB; Nitrosative stress; PEP; PK; PPIA; Proteomics; PrxIII; ROS; TCA; TGS; TNFα; TPI; TrisglycineSDS; VDR; VitD; VitD3; Vitamin D; alkaline phosphatase activity buffer; amyloid-ß peptide; bovine serum albumin; calcidiol, 25-hydroxyvitamin D; calcitriol, 1α,25-dihydroxyvitamin D; cholecalciferol; deionized; dithiothreitol; glutathione peroxidase; iNOS; inducible nitric oxide synthase; inferior parietal lobule; iodoacetamide; isoelectric focusing; manganese superoxide dismutase; mass spectrometry; nitroblue tetrazolium; nuclear factor κ-light-chain enhancer of activated B cells; peptidylprolyl cistrans isomerase A; peroxiredoxin 3; phosphoenolpyruvate; pyruvate kinase; reactive oxygen species; tricarboxylic acid; triose phosphate isomerase; tumor necrosis factor-α; two-dimensional polyacrylamide gel electrophoresis; vitamin D; vitamin D receptor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Deficiencia de Vitamina D / Encéfalo / Trastornos del Conocimiento Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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