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Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
Gao, Qiang; Mechin, Ingrid; Kothari, Nayantara; Guo, Zhuyan; Deng, Gejing; Haas, Kimberly; McManus, Jessica; Hoffmann, Dietmar; Wang, Anlai; Wiederschain, Dmitri; Rocnik, Jennifer; Czechtizky, Werngard; Chen, Xin; McLean, Larry; Arlt, Heike; Harper, David; Liu, Feng; Majid, Tahir; Patel, Vinod; Lengauer, Christoph; Garcia-Echeverria, Carlos; Zhang, Bailin; Cheng, Hong; Dorsch, Marion; Huang, Shih-Min A.
Afiliación
  • Gao Q; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Mechin I; Tucson Research Center, Sanofi, Tucson, Arizona 85755.
  • Kothari N; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Guo Z; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Deng G; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Haas K; Lead Generation and Candidate Realization, Sanofi, Bridgewater, New Jersey 08807, and.
  • McManus J; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Hoffmann D; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Wang A; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Wiederschain D; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Rocnik J; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Czechtizky W; Lead Generation and Candidate Realization, Sanofi, Industriepark Höchst, 65926 Frankfurt, Germany.
  • Chen X; Lead Generation and Candidate Realization, Sanofi, Bridgewater, New Jersey 08807, and.
  • McLean L; Lead Generation and Candidate Realization, Sanofi, Bridgewater, New Jersey 08807, and.
  • Arlt H; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Harper D; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Liu F; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Majid T; Lead Generation and Candidate Realization, Sanofi, Waltham, Massachusetts 02451.
  • Patel V; Lead Generation and Candidate Realization, Sanofi, Waltham, Massachusetts 02451.
  • Lengauer C; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Garcia-Echeverria C; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Zhang B; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Cheng H; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Dorsch M; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France.
  • Huang SA; From Discovery and Early Development, Sanofi Oncology, Cambridge, Massachusetts 02139 and 94400 Vitry-sur-Seine Cedex, France,. Electronic address: alex.huang@sanofi.com.
J Biol Chem ; 288(42): 30125-30138, 2013 Oct 18.
Article en En | MEDLINE | ID: mdl-24003220
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleoproteína Nuclear Pequeña U4-U6 / Inhibidores de Proteínas Quinasas / Proteínas de Neoplasias / Neoplasias Límite: Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article País de afiliación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleoproteína Nuclear Pequeña U4-U6 / Inhibidores de Proteínas Quinasas / Proteínas de Neoplasias / Neoplasias Límite: Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article País de afiliación: Francia