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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.
Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X; Nair, Anilkumar G; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Heimark, Larry; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; Njoroge, F George.
Afiliación
  • Venkatraman S; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address: Srikanth.Venkatraman@merck.com.
  • Velazquez F; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Gavalas S; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Wu W; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Chen KX; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Nair AG; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Bennett F; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Huang Y; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Pinto P; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Jiang Y; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Selyutin O; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Vibulbhan B; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Zeng Q; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Lesburg C; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Duca J; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Heimark L; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Huang HC; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Agrawal S; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Jiang CK; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Ferrari E; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Li C; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Kozlowski J; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Rosenblum S; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Shih NY; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Njoroge FG; Merck Research Laboratories, K15, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.
Bioorg Med Chem ; 22(1): 447-58, 2014 Jan 01.
Article en En | MEDLINE | ID: mdl-24275348
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas no Estructurales Virales / Hepacivirus / Ésteres / Indoles Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas no Estructurales Virales / Hepacivirus / Ésteres / Indoles Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article