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ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
Van Schaeybroeck, Sandra; Kalimutho, Murugan; Dunne, Philip D; Carson, Robbie; Allen, Wendy; Jithesh, Puthen V; Redmond, Keara L; Sasazuki, Takehiko; Shirasawa, Senji; Blayney, Jaine; Michieli, Paolo; Fenning, Cathy; Lenz, Heinz-Josef; Lawler, Mark; Longley, Daniel B; Johnston, Patrick G.
Afiliación
  • Van Schaeybroeck S; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Kalimutho M; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Dunne PD; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Carson R; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Allen W; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Jithesh PV; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Redmond KL; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Sasazuki T; Institute for Advanced Study, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
  • Shirasawa S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan-Ku, Fukuoka 814-0180, Japan.
  • Blayney J; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Michieli P; Laboratory of Experimental Therapy, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino 10060, Italy; Department of Oncology, University of Torino Medical School, Candiolo, Torino 10060, Italy.
  • Fenning C; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Lenz HJ; Division of Medical Oncology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA.
  • Lawler M; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Longley DB; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
  • Johnston PG; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK. Electronic address: p.johnston@qub.ac.uk.
Cell Rep ; 7(6): 1940-55, 2014 Jun 26.
Article en En | MEDLINE | ID: mdl-24931611
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas / Proteínas ras / Proteínas Proto-Oncogénicas c-met / Quinasas Quinasa Quinasa PAM / Inhibidores de Proteínas Quinasas / Proteínas ADAM / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas / Proteínas ras / Proteínas Proto-Oncogénicas c-met / Quinasas Quinasa Quinasa PAM / Inhibidores de Proteínas Quinasas / Proteínas ADAM / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos