Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
J Nat Prod
; 77(9): 2054-9, 2014 Sep 26.
Article
en En
| MEDLINE
| ID: mdl-25222040
ABSTRACT
Biotransformation of huperzine A (hupA) by a fungal endophyte, Ceriporia lacerate HS-ZJUT-C13A, afforded compounds 1-5 and three tremulane sesquiterpenoids, 6-8. Huptremules A-D (1-4) feature unusual sesquiterpenoid-alkaloid hybrid structures that integrate the characteristics of fungal metabolites (tremulane sesquiterpenoids) and the exogenous substrate (hupA). These results support the use of fungal endophytes as biocatalysts for the biotransformation of natural products, particularly those originating from the host plant.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Productos Biológicos
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Inhibidores de la Colinesterasa
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Huperzia
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Alcaloides
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Endófitos
Idioma:
En
Revista:
J Nat Prod
Año:
2014
Tipo del documento:
Article