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Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Fares, Iman; Chagraoui, Jalila; Gareau, Yves; Gingras, Stéphane; Ruel, Réjean; Mayotte, Nadine; Csaszar, Elizabeth; Knapp, David J H F; Miller, Paul; Ngom, Mor; Imren, Suzan; Roy, Denis-Claude; Watts, Kori L; Kiem, Hans-Peter; Herrington, Robert; Iscove, Norman N; Humphries, R Keith; Eaves, Connie J; Cohen, Sandra; Marinier, Anne; Zandstra, Peter W; Sauvageau, Guy.
Afiliación
  • Fares I; Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.
  • Chagraoui J; Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.
  • Gareau Y; Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.
  • Gingras S; Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.
  • Ruel R; Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.
  • Mayotte N; Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.
  • Csaszar E; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • Knapp DJ; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Miller P; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Ngom M; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Imren S; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Roy DC; Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada. Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.
  • Watts KL; Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA.
  • Kiem HP; Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA. Department of Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Herrington R; Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
  • Iscove NN; Ontario Cancer Institute, University Health Network, Toronto, ON, Canada. Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Humphries RK; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Eaves CJ; Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
  • Cohen S; Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada. Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.
  • Marinier A; Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.
  • Zandstra PW; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • Sauvageau G; Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada. Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada. Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal
Science ; 345(6203): 1509-12, 2014 Sep 19.
Article en En | MEDLINE | ID: mdl-25237102
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Regeneración / Células Madre Hematopoyéticas / Receptores de Hidrocarburo de Aril / Sangre Fetal / Hematopoyesis / Indoles Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Science Año: 2014 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Regeneración / Células Madre Hematopoyéticas / Receptores de Hidrocarburo de Aril / Sangre Fetal / Hematopoyesis / Indoles Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Science Año: 2014 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos