Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4.

Rock, Brooke M; Hengel, Shawna M; Rock, Dan A; Wienkers, Larry C; Kunze, Kent L

Rock, Brooke M; Hengel, Shawna M; Rock, Dan A; Wienkers, Larry C; Kunze, Kent L.

Afiliación

Rock BM; Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, Washington (B.M.R., D.A.R., L.C.W.); and Department of Medicinal Chemistry, University of Washington, Seattle, Washington (S.M.H., K.L.K.) brooke@amgen.com.
Hengel SM; Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, Washington (B.M.R., D.A.R., L.C.W.); and Department of Medicinal Chemistry, University of Washington, Seattle, Washington (S.M.H., K.L.K.).
Rock DA; Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, Washington (B.M.R., D.A.R., L.C.W.); and Department of Medicinal Chemistry, University of Washington, Seattle, Washington (S.M.H., K.L.K.).
Wienkers LC; Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, Washington (B.M.R., D.A.R., L.C.W.); and Department of Medicinal Chemistry, University of Washington, Seattle, Washington (S.M.H., K.L.K.).
Kunze KL; Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, Washington (B.M.R., D.A.R., L.C.W.); and Department of Medicinal Chemistry, University of Washington, Seattle, Washington (S.M.H., K.L.K.).

Mol Pharmacol ; 86(6): 665-74, 2014 Dec.

Article en En | MEDLINE | ID: mdl-25274602

Asunto(s)

Inhibidores del Citocromo P-450 CYP3A/farmacología; Ritonavir/farmacología; Citocromo P-450 CYP3A/química; Humanos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritonavir / Inhibidores del Citocromo P-450 CYP3A Límite: Humans Idioma: En Revista: Mol Pharmacol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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