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Correlates of virulence in a frog-killing fungal pathogen: evidence from a California amphibian decline.
Piovia-Scott, Jonah; Pope, Karen; Worth, S Joy; Rosenblum, Erica Bree; Poorten, Thomas; Refsnider, Jeanine; Rollins-Smith, Louise A; Reinert, Laura K; Wells, Heather L; Rejmanek, Dan; Lawler, Sharon; Foley, Janet.
Afiliación
  • Piovia-Scott J; Department of Biology, University of California, Riverside, CA, USA.
  • Pope K; Pacific Southwest Research Station, United States Forest Service, Arcata, CA, USA.
  • Worth SJ; Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA, USA.
  • Rosenblum EB; Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA.
  • Poorten T; Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA.
  • Refsnider J; Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA.
  • Rollins-Smith LA; 1] Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA [2] Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA [3] Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
  • Reinert LK; 1] Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA [2] Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Wells HL; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
  • Rejmanek D; Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA, USA.
  • Lawler S; Department of Entomology, University of California, Davis, CA, USA.
  • Foley J; Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA, USA.
ISME J ; 9(7): 1570-8, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25514536
The fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused declines and extinctions in amphibians worldwide, and there is increasing evidence that some strains of this pathogen are more virulent than others. While a number of putative virulence factors have been identified, few studies link these factors to specific epizootic events. We documented a dramatic decline in juvenile frogs in a Bd-infected population of Cascades frogs (Rana cascadae) in the mountains of northern California and used a laboratory experiment to show that Bd isolated in the midst of this decline induced higher mortality than Bd isolated from a more stable population of the same species of frog. This highly virulent Bd isolate was more toxic to immune cells and attained higher density in liquid culture than comparable isolates. Genomic analyses revealed that this isolate is nested within the global panzootic lineage and exhibited unusual genomic patterns, including increased copy numbers of many chromosomal segments. This study integrates data from multiple sources to suggest specific phenotypic and genomic characteristics of the pathogen that may be linked to disease-related declines.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ranidae / Quitridiomicetos / Micosis Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: ISME J Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ranidae / Quitridiomicetos / Micosis Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: ISME J Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido