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Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study.
Fan, W-C; Liu, C-J; Hong, Y-C; Feng, J-Y; Su, W-J; Chien, S-H; Chen, T-J; Chiang, C-H.
Afiliación
  • Fan WC; Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Liu CJ; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
  • Hong YC; Division of Hematology and Oncology, Department of Medicine, Kaoshiung Veterans General Hospital, Kaohsiung City, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Feng JY; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Su WJ; School of Medicine, National Yang-Ming University, Taipei, , Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chien SH; School of Medicine, National Yang-Ming University, Taipei, , Taiwan; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chen TJ; School of Medicine, National Yang-Ming University, Taipei, , Taiwan; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chiang CH; Division of Cardiology, Department of Medicine, Da-Chien General Hospital, Miaoli, , Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine
Int J Tuberc Lung Dis ; 19(1): 58-64, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25519791
BACKGROUND: Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited. METHODS: We obtained data on 2040 HSCT recipients from the Registry of Catastrophic Illness in Taiwan from 1997 to 2006. We also obtained data on age-, sex- and enrolment date-matched controls from the Longitudinal Health Insurance Database. The cumulative incidence of active TB in HSCT recipients and controls and risk factors for TB were analysed. RESULTS: Among 2040 HSCT recipients identified, 39 (1.9%) had newly diagnosed TB. The incidence rate was 688 per 100 000 person-years. The 10-year cumulative TB incidence was respectively 3.52% and 0.38% in HSCT recipients and controls (P < 0.001). HSCT was an independent risk factor for TB compared with matched controls. Among post-HSCT patients, independent risk factors for TB included age ⩾18 years and allogeneic recipients with graft-versus-host disease (GVHD). Post-HSCT patients with subsequent TB had a higher mortality rate than those without TB (P < 0.001). CONCLUSION: HSCT is associated with an increased risk of TB in endemic regions. Older age and development of chronic GVHD are independent predictors of late onset active TB in HSCT recipients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Trasplante de Células Madre Hematopoyéticas / Receptores de Trasplantes / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Año: 2015 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Trasplante de Células Madre Hematopoyéticas / Receptores de Trasplantes / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Año: 2015 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Francia