Ready to benefit from training: heterologous effects of early life immunization.
Trans R Soc Trop Med Hyg
; 109(1): 3-4, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-25573103
ABSTRACT
Trained immunity reflects the ability of the innate immune system to adapt via epigenetic changes in monocytes, enhancing responses to a range of microbes, thereby potentially reducing infection in high-risk populations. Examples of trained immunity at birth include enhanced resistance to infection in TLR-simulated newborn mice, reduced risk of late onset sepsis with histologic chorioamnionitis and beneficial heterologous effects of neonatal bacille Calmette-Guérin administration in reducing diverse infections during infancy. Future efforts will assess leveraging trained immunity in early life by administering 'stand-alone' innate immune stimuli or (self-)adjuvanted vaccines to protect against a broad range of infections.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Efectos Tardíos de la Exposición Prenatal
/
Enfermedades Transmisibles
/
Inmunización
/
Inmunidad Adaptativa
/
Inmunidad Heteróloga
/
Inmunidad Innata
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos