Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor &#954;B ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.

Plotkin, Lilian I; Gortazar, Arancha R; Davis, Hannah M; Condon, Keith W; Gabilondo, Hugo; Maycas, Marta; Allen, Matthew R; Bellido, Teresita

Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.

Plotkin, Lilian I; Gortazar, Arancha R; Davis, Hannah M; Condon, Keith W; Gabilondo, Hugo; Maycas, Marta; Allen, Matthew R; Bellido, Teresita.

Afiliación

Plotkin LI; From the Departments of Anatomy and Cell Biology and the Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202 lplotkin@iupui.edu.
Gortazar AR; From the Departments of Anatomy and Cell Biology and.
Davis HM; From the Departments of Anatomy and Cell Biology and.
Condon KW; From the Departments of Anatomy and Cell Biology and.
Gabilondo H; From the Departments of Anatomy and Cell Biology and.
Maycas M; From the Departments of Anatomy and Cell Biology and.
Allen MR; From the Departments of Anatomy and Cell Biology and.
Bellido T; From the Departments of Anatomy and Cell Biology and the Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202 Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana 46202 and tbellido@iupui.edu.

J Biol Chem ; 290(31): 18934-42, 2015 Jul 31.

Article en En | MEDLINE | ID: mdl-26085098

Asunto(s)

Apoptosis/efectos de los fármacos; Resorción Ósea/metabolismo; Colágeno Tipo I/farmacología; Osteocitos/fisiología; Péptidos/farmacología; Ligando RANK/metabolismo; Alendronato/farmacología; Animales; Conservadores de la Densidad Ósea/farmacología; Células Cultivadas; Femenino; Suspensión Trasera; Ratones Endogámicos C57BL; Osteocitos/efectos de los fármacos

Palabras clave

RANKL; apoptosis; bone; immobilization; osteoblast; osteoclast; osteocyte; resorption

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteocitos / Péptidos / Resorción Ósea / Apoptosis / Colágeno Tipo I / Ligando RANK Límite: Animals Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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