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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Sison-Young, Rowena L C; Mitsa, Dimitra; Jenkins, Rosalind E; Mottram, David; Alexandre, Eliane; Richert, Lysiane; Aerts, Hélène; Weaver, Richard J; Jones, Robert P; Johann, Esther; Hewitt, Philip G; Ingelman-Sundberg, Magnus; Goldring, Christopher E P; Kitteringham, Neil R; Park, B Kevin.
Afiliación
  • Sison-Young RL; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Mitsa D; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Jenkins RE; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Mottram D; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Alexandre E; KaLy-Cell, Research & Development, 67115 Plobsheim, France;
  • Richert L; KaLy-Cell, Research & Development, 67115 Plobsheim, France;
  • Aerts H; Biologie Servier, 905 Route de Saran, 45520, Gidy, France;
  • Weaver RJ; Biologie Servier, 905 Route de Saran, 45520, Gidy, France;
  • Jones RP; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Johann E; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool L9 7AL, UK;
  • Hewitt PG; Merck KGaA, Merck Serono, Non-Clinical Safety, 64293 Darmstadt, Germany; and.
  • Ingelman-Sundberg M; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.
  • Goldring CE; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
  • Kitteringham NR; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK; neilk@liverpool.ac.uk.
  • Park BK; *Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, Liverpool L69 3GE, UK;
Toxicol Sci ; 147(2): 412-24, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26160117
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatocitos / Proteómica / Hígado Límite: Humans Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatocitos / Proteómica / Hígado Límite: Humans Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos