Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.

Tsunoda, Toshiyuki; Ishikura, Shuhei; Doi, Keiko; Iwaihara, Yuri; Hidesima, Hiromasa; Luo, Hao; Hirose, Yumiko; Shirasawa, Senji

Tsunoda, Toshiyuki; Ishikura, Shuhei; Doi, Keiko; Iwaihara, Yuri; Hidesima, Hiromasa; Luo, Hao; Hirose, Yumiko; Shirasawa, Senji.

Afiliación

Tsunoda T; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Ishikura S; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Doi K; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Iwaihara Y; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan.
Hidesima H; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan.
Luo H; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan.
Hirose Y; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan.
Shirasawa S; Department of Cell Biology, Faculty of Medicine Fukuoka University, Fukuoka, Japan Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan sshirasa@fukuoka-u.ac.jp.

Anticancer Res ; 35(8): 4453-9, 2015 Aug.

Article en En | MEDLINE | ID: mdl-26168486

Asunto(s)

Técnicas de Cultivo de Célula/métodos; Neoplasias Colorrectales/tratamiento farmacológico; Ensayos de Selección de Medicamentos Antitumorales/métodos; Terapia Molecular Dirigida; Proteínas Proto-Oncogénicas/metabolismo; Proteínas ras/metabolismo; Línea Celular Tumoral; Neoplasias Colorrectales/patología; Regulación Neoplásica de la Expresión Génica; Células HCT116; Humanos; Proteínas Proto-Oncogénicas/efectos de los fármacos; Proteínas Proto-Oncogénicas/genética; Proteínas Proto-Oncogénicas p21(ras); Proteínas ras/efectos de los fármacos; Proteínas ras/genética

Palabras clave

3-dimensional floating culture; KRAS; colorectal cancer; drug screening

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos de Selección de Medicamentos Antitumorales / Neoplasias Colorrectales / Proteínas Proto-Oncogénicas / Proteínas ras / Técnicas de Cultivo de Célula / Terapia Molecular Dirigida Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Anticancer Res Año: 2015 Tipo del documento: Article País de afiliación: Japón

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