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Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.
Uno, Tomohide; Ogura, Chika; Izumi, Chiho; Nakamura, Masahiko; Yanase, Takeshi; Yamazaki, Hiroshi; Ashida, Hitoshi; Kanamaru, Kengo; Yamagata, Hiroshi; Imaishi, Hiromasa.
Afiliación
  • Uno T; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Ogura C; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Izumi C; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Nakamura M; Department of Bioscience and Biotechnology, Faculty of Bioenvironmental Science, Kyoto Gakuen University, 1-1 Nanjo, Sogabe, Kameoka, Kyoto, 621-8555, Japan.
  • Yanase T; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
  • Ashida H; Laboratory of Biochemistry Frontiers, Graduate School of Agricultural Science, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Kanamaru K; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Yamagata H; Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
  • Imaishi H; Functional Analysis of Environmental Genes, Research Center for Environmental Genomics, Kobe University, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
Biopharm Drug Dispos ; 36(8): 552-63, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26222491
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Mutación Puntual / Polimorfismo de Nucleótido Simple / Citocromo P-450 CYP2A6 Idioma: En Revista: Biopharm Drug Dispos Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Mutación Puntual / Polimorfismo de Nucleótido Simple / Citocromo P-450 CYP2A6 Idioma: En Revista: Biopharm Drug Dispos Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido