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Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Onions, Stuart T; Ito, Kazuhiro; Charron, Catherine E; Brown, Richard J; Colucci, Marie; Frickel, Fritz; Hardy, George; Joly, Kevin; King-Underwood, John; Kizawa, Yasuo; Knowles, Ian; Murray, P John; Novak, Andrew; Rani, Anjna; Rapeport, Garth; Smith, Alun; Strong, Peter; Taddei, David M; Williams, Jonathan G.
Afiliación
  • Onions ST; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Ito K; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Charron CE; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Brown RJ; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Colucci M; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Frickel F; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Hardy G; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Joly K; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • King-Underwood J; CompChem Resource , Old Cottage Hospital, Homend, Ledbury, Herefordshire HR8 1ED, United Kingdom.
  • Kizawa Y; Department of Physiology and Anatomy, Nihon University School of Pharmacy , 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan.
  • Knowles I; Pneumolabs UK Limited , Harrow, Middlesex HA1 3UJ, United Kingdom.
  • Murray PJ; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Novak A; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Rani A; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Rapeport G; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Smith A; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Strong P; RespiVert Limited , 2 Royal College Street, The London Bioscience Innovation Centre, London NW1 0NH, United Kingdom.
  • Taddei DM; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
  • Williams JG; Sygnature Discovery Limited, Biocity , Nottingham NG1 1GF, United Kingdom.
J Med Chem ; 59(5): 1727-46, 2016 Mar 10.
Article en En | MEDLINE | ID: mdl-26800309
The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Asma / Enfermedad Pulmonar Obstructiva Crónica / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Asma / Enfermedad Pulmonar Obstructiva Crónica / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos