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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.
Nywening, Timothy M; Wang-Gillam, Andrea; Sanford, Dominic E; Belt, Brian A; Panni, Roheena Z; Cusworth, Brian M; Toriola, Adetunji T; Nieman, Rebecca K; Worley, Lori A; Yano, Motoyo; Fowler, Kathryn J; Lockhart, A Craig; Suresh, Rama; Tan, Benjamin R; Lim, Kian-Huat; Fields, Ryan C; Strasberg, Steven M; Hawkins, William G; DeNardo, David G; Goedegebuure, S Peter; Linehan, David C.
Afiliación
  • Nywening TM; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Wang-Gillam A; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Sanford DE; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
  • Belt BA; Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA; Center for Tumor Immunology, University of Rochester Medical Center, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
  • Panni RZ; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
  • Cusworth BM; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Toriola AT; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Division of Public Health Sciences, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Nieman RK; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Worley LA; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Yano M; Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Fowler KJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Lockhart AC; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Suresh R; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Tan BR; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Lim KH; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Fields RC; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Strasberg SM; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Hawkins WG; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • DeNardo DG; Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Goedegebuure SP; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
  • Linehan DC; Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA; Center for Tumor Immunology, University of Rochester Medical Center, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: david_linehan@urmc.roch
Lancet Oncol ; 17(5): 651-62, 2016 05.
Article en En | MEDLINE | ID: mdl-27055731
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pirrolidinas / Protocolos de Quimioterapia Combinada Antineoplásica / Receptores CCR2 Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pirrolidinas / Protocolos de Quimioterapia Combinada Antineoplásica / Receptores CCR2 Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos