An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase.

Tchesnokov, E P; Faponle, A S; Davies, C G; Quesne, M G; Turner, R; Fellner, M; Souness, R J; Wilbanks, S M; de Visser, S P; Jameson, G N L

Tchesnokov, E P; Faponle, A S; Davies, C G; Quesne, M G; Turner, R; Fellner, M; Souness, R J; Wilbanks, S M; de Visser, S P; Jameson, G N L.

Afiliación

Tchesnokov EP; Department of Chemistry & MacDiarmid Institute for Advanced Materials and Nanotechnology University of Otago, PO Box 56, Dunedin 9054, New Zealand. guy.jameson@otago.ac.nz.
Faponle AS; Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. sam.devisser@manchester.ac.uk.
Davies CG; Department of Chemistry & MacDiarmid Institute for Advanced Materials and Nanotechnology University of Otago, PO Box 56, Dunedin 9054, New Zealand. guy.jameson@otago.ac.nz.
Quesne MG; Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. sam.devisser@manchester.ac.uk.
Turner R; Centre for Free Radical Research, University of Otago, 2 Riccarton Ave, PO Box 4345, Christchurch, New Zealand.
Fellner M; Department of Chemistry & MacDiarmid Institute for Advanced Materials and Nanotechnology University of Otago, PO Box 56, Dunedin 9054, New Zealand. guy.jameson@otago.ac.nz.
Souness RJ; Department of Chemistry & MacDiarmid Institute for Advanced Materials and Nanotechnology University of Otago, PO Box 56, Dunedin 9054, New Zealand. guy.jameson@otago.ac.nz.
Wilbanks SM; Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
de Visser SP; Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. sam.devisser@manchester.ac.uk.
Jameson GN; Department of Chemistry & MacDiarmid Institute for Advanced Materials and Nanotechnology University of Otago, PO Box 56, Dunedin 9054, New Zealand. guy.jameson@otago.ac.nz.

Chem Commun (Camb) ; 52(57): 8814-7, 2016 Jul 07.

Article en En | MEDLINE | ID: mdl-27297454

RESUMEN

Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.

Asunto(s)

Biocatálisis; Cisteína-Dioxigenasa/metabolismo; Hierro/metabolismo; Oxígeno/metabolismo; Hierro/química; Conformación Molecular; Oxígeno/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Cisteína-Dioxigenasa / Biocatálisis / Hierro Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido

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