[Effect of fenofibrate on fibrinogen concentration and blood viscosity. Consequences for myocardial microcirculation in coronary heart disease?]. / Einfluss von Fenofibrat auf Fibrinogenkonzentration und Blutfluidität. Konsequenzen für die myokardiale Mikrozirkulation bei der koronaren Herzerkrankung?
Dtsch Med Wochenschr
; 114(24): 939-44, 1989 Jun 16.
Article
en De
| MEDLINE
| ID: mdl-2731478
ABSTRACT
The effect of fenofibrate (a clofibrate derivative) on fibrinogen concentration, blood viscosity and myocardial microcirculation was examined in 35 patients with coronary heart disease (n = 27) or hypertension (n = 8). After eight weeks' administration of 250 mg fenofibrate daily cholesterol and triglycerides levels decreased significantly, as did the fibrinogen concentration, from a mean of 300.7 +/- 75.1 mg/dl to 252.3 +/- 61.2 mg/dl (P less than 0.01). Plasma viscosity and erythrocyte aggregation were also significantly lowered (from 1.43 +/- 0.09 to 1.37 +/- 0.07 mPas and 15.0 +/- 3.1 to 13.5 +/- 2.2, respectively; P less than 0.01). In eight of twelve subjects selected from the whole group thallium myocardial scintigraphy demonstrated, after eight weeks of treatment with fenofibrate, a global (in two) or regional (in six) increase in blood flow. Reduction of fibrinogen concentration may in coronary heart disease achieve an improvement in myocardial microcirculation with decreased myocardial ischaemia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenofibrato
/
Propionatos
/
Viscosidad Sanguínea
/
Fibrinógeno
/
Circulación Coronaria
/
Enfermedad Coronaria
Límite:
Humans
Idioma:
De
Revista:
Dtsch Med Wochenschr
Año:
1989
Tipo del documento:
Article