Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro.
Food Chem
; 212: 282-90, 2016 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-27374534
Spent coffee grounds (SCG), rich in dietary fiber can be fermented by colon microbiota producing short-chain fatty acids (SCFAs) with the ability to prevent inflammation. We investigated SCG anti-inflammatory effects by evaluating its composition, phenolic compounds, and fermentability by the human gut flora, SCFAs production, nitric oxide and cytokine expression of the human gut fermented-unabsorbed-SCG (hgf-NDSCG) fraction in LPS-stimulated RAW 264.7 macrophages. SCG had higher total fiber content compared with coffee beans. Roasting level/intensity reduced total phenolic contents of SCG that influenced its colonic fermentation. Medium roasted hgf-NDSCG produced elevated SCFAs (61:22:17, acetate, propionate and butyrate) after prolonged (24h) fermentation, suppressed NO production (55%) in macrophages primarily by modulating IL-10, CCL-17, CXCL9, IL-1ß, and IL-5 cytokines. SCG exerts anti-inflammatory activity, mediated by SCFAs production from its dietary fiber, by reducing the release of inflammatory mediators, providing the basis for SCG use in the control/regulation of inflammatory disorders. The results support the use of SGC in the food industry as dietary fiber source with health benefits.
Palabras clave
Acetic acid (PubChem CID: 176); Butyric acid (PubChem CID: 264); Caffeic acid (PubChem CID: 689043); Caffeine (PubChem CID: 2519); Catechin (PubChem CID: 9064); Chlorogenic acid (PubChem CID: 1794427); Cytokines; Gallic acid (PubChem CID: 370); In vitro colonic fermentation; In vitro gastrointestinal digestion; Inflammation; Nitric oxide; Nitric oxide (PubChem CID: 145068); Propionic acid (PubChem CID: 1032); Rutin (PubChem CID: 5280805); Spent coffee grounds
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Café
/
Colon
/
Fermentación
/
Inflamación
/
Macrófagos
/
Antiinflamatorios
Límite:
Humans
Idioma:
En
Revista:
Food Chem
Año:
2016
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Reino Unido