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IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Takatani, Tomozumi; Shirakawa, Jun; Roe, Michael W; Leech, Colin A; Maier, Bernhard F; Mirmira, Raghavendra G; Kulkarni, Rohit N.
Afiliación
  • Takatani T; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Shirakawa J; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Roe MW; Department of Medicine, State University of New York (SUNY), Upstate Medical University, Syracuse, NY, USA.
  • Leech CA; Department of Medicine, State University of New York (SUNY), Upstate Medical University, Syracuse, NY, USA.
  • Maier BF; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Mirmira RG; Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Kulkarni RN; Department of Cellular and Integrative Physiology, Department of Biochemistry and Molecular Biology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Sci Rep ; 6: 28177, 2016 07 05.
Article en En | MEDLINE | ID: mdl-27378176
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calcio / Células Secretoras de Insulina / Proteínas Sustrato del Receptor de Insulina / Proteína 1 de Unión a la X-Box Límite: Animals Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calcio / Células Secretoras de Insulina / Proteínas Sustrato del Receptor de Insulina / Proteína 1 de Unión a la X-Box Límite: Animals Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos